Different patterns of myocardial iron overload by T2* Cardiovascular MR as markers of risk for cardiac complication in thalassemia major

نویسندگان

  • Antonella Meloni
  • Vincenzo Positano
  • Petra Keilberg
  • Brunella Favilli
  • Claudio Ascioti
  • Gianluca Valeri
  • Angelo Zuccarelli
  • Anna Pietrapertosa
  • Massimo Lombardi
  • Alessia Pepe
چکیده

Background Cardiac complications mainly related to myocardial iron overload (MIO) remain the main cause of morbidity and mortality in thalassemia major (TM). Thalassemia cardiomyopathy is treatable and partly reversible if appropriate chelation therapy is instituted in time. The validated multislice multiecho T2* Cardiovascular Magnetic Resonance (CMR) technique has permitted to quantify segmental and global myocardial iron burden detecting different patterns of iron overload. Aim of our study was to verify the risk of cardiac complications related to different patterns of MIO in a large cohort of TM patients.

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عنوان ژورنال:

دوره 14  شماره 

صفحات  -

تاریخ انتشار 2012